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3-dehydrosphinganine reductase : ウィキペディア英語版 | 3-dehydrosphinganine reductase
3-dehydrosphinganine reductase () also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the ''KDSR'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2531 )〕 == Function ==
3-dehydrosphinganine reductase catalyzes the chemical reaction: :sphinganine + NADP+ 3-dehydrosphinganine + NADPH + H+ Thus, the two substrates of this enzyme are sphinganine and NADP+, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in sphingolipid metabolism.
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